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Oxidative stress and hyper-inflammation as major drivers of severe COVID-19 and Long COVID: implications for the benefit of high-dose intravenous vitamin C

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Several changes in structural (reduced tendon CSA and fibril diameter), cellular (decreased cell proliferation and stem/progenitor cell quantity), and mechanical properties (reduced modulus and strength), beyond just alterations to AGE-mediated crosslinks, occur in tendon during the aging process and have been recently reviewed in detail (Svensson et al ., 2016)